Hexonic P-line heat exchangers meet the challenges offered by the pharmaceutical industry. They also meet its restrictive hygienic standards imposed by inspection authorities and the industry.
The HEXONIC P-line heat exchanger is a shell and tube heat exchanger developed to meet the demanding requirements of the pharmaceutical industry. It is designed for safe, sterile operation and complies with restrictive hygienic standards imposed by both inspection authorities and the industry itself.
The P-line was created to minimise contamination risk and ensure secure separation between the pharmaceutical product and the service medium. Its double tubesheet design prevents media mixing even in the event of leakage and allows immediate detection of potential malfunction. Combined with polished inner tube surfaces, low roughness, complete drainability by gravity, and low pressure losses, the P-line is engineered for long-term, hygienic pharmaceutical duty.
Key Features
- Designed for pharmaceutical production: The P-line is specifically intended for pharmaceutical applications and meets the highest hygienic standards.
- Double tubesheet protection: The double tubesheet provides additional protection against mixing of the pharmaceutical product with the other medium and enables immediate leak detection.
- High hygienic surface finish: Surfaces in contact with the pure medium are polished to Ra ≤ 0.5 µm / 19.7 µin, supporting precise cleaning and hygienic operation.
- Complete drainability:Thanks to low-roughness tubes and proper connector placement, the exchanger can be completely emptied using gravity alone.
- Reduced sediment accumulation: Polished inner tube surfaces hinder deposit build-up, which is critical in pharmaceutical systems.
- Low pressure losses: The exchanger is designed to ensure very low pressure drops while maintaining sanitary performance.
- Certified and compliant: The P-line is 3-A certified and manufactured in accordance with cGMP, PED, and ASME.
- All-stainless construction: The exchanger is made entirely of stainless steel for long-term, safe operation.
- Flexible configuration:One, two, and four-pass designs are available, as well as horizontal and vertical models.
Design
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Head
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Triclamp connection
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Certified gasketsmade of silicone and Viton and clean side Triclamp connections
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Double tubesheetreduces the risk of media mixing in case of potential leakage
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Straight stainless tubeswith diameter 8 mm or 12.7 mm
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Corrugated tube option for enhanced flow turbulencewith diameter of 8 mm
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Expansion jointusing the method of pressure expansion with clean water at pressures up to 6000 bar, which eliminates the risk of damaging their internal surface
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Tubes are connected with tubesheetsusing the pressure expansion method with pure pressurized water up to 6000 bar, which eliminates the risk of damaging their inner surface
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Tubes are connected with the external tubesheetthe tubes, expanded using the pressure method, are welded to the external tubesheet using pure argon shield method
P-line application in WFI manufacturing
Technical Specifications
| Parameter | Specification |
|---|---|
| Design Standards | PED; ASME, |
| Max Design Pressure | tubes: 10 bar / 145 PSI; shell: 10 bar/ 145 PSI |
| Max Design Temperature | tubes: VITON — 140°C ⁄ 284 ° F; SILICON — 121°C* ⁄ 249 ° F); shell: 200°C / 392°F |
| Shell Diameter Range | 60.3–273 mm/2.4-10.7 in |
| Tube Materials | stainless steel 316L / 1.4404; straight tubes Ø 8 mm(0.3 in) or 12.7 mm(0.5 in) ; corrugated tube option Ø 8 mm(0.3 in) |
| Shell Materials | stainless steel 316L / 1.4404 |
| Design Types | one-pass, two-pass and four-pass; horizontal and vertical; double tubesheet |
| Connection Types | Connection Types: flange or tri-clamp, stainless steel; EN 1092-1 PN16 01B / ASME B16.5 Class 150 SORF; DIN 32676 Type A / ASME BPE Type B Connection Size Range: Type 1P: DN25–DN100 / 1″–4″ Type 2P: DN50–DN100 / 2″–4″ Type 4P: DN50–DN100 / 2″–4″ |
| Certification | 3-A certified, cGMP; PED; ASME |
Applications
Pharmaceutical exchanger
it was designed to minimize the contamination risk and ensure safe and sterile operation
Quality guarantee
airtightness and high quality make of exchangers are confirmed during pressure testing and quality control
Technical support
we help selecting appropriate exchanger for particular application and technical requirements
Certificates and standards
the exchangers are manufactured in accordance with PED, ASME, 3-A, cGMP (FDA)
Frequently Asked Questions
The HEXONIC P-line is designed for pharmaceutical production and other sterile applications that require very high hygienic standards, secure media separation, and reliable cleanability. The page also highlights its use in WFI generation, storage, distribution, and point-of-use systems.
The exchanger uses a double tubesheet design that prevents mixing between the pharmaceutical product and the other medium even in the event of leakage. This configuration also allows immediate detection of potential malfunction.
The pure-medium contact surfaces are polished to Ra ≤ 0.5 µm / 19.7 µin, the inner tube surfaces are polished to reduce sediment accumulation, and the connector placement allows the exchanger to be completely emptied using gravity alone.
The P-line is 3-A certified and manufactured in accordance with cGMP, PED, and ASME.
